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Fig. 5 | Respiratory Research

Fig. 5

From: Administration of JTE013 abrogates experimental asthma by regulating proinflammatory cytokine production from bronchial epithelial cells

Fig. 5

Simplified scheme of the S1PR2 signaling events in airway epithelial cells. On airway epithelial cells, S1P binds to S1PR2, which is coupled to GaI, Ga12/13, and GaQ. GaQ in turn activates PLC, activating PKC. PKC phosphorylates NFκB, which binds to the proximal promotor of CCL3 major nuclear proteins. In addition, another S1PR2-coupled G protein, Ga12/13, also up-regulates CCL3 expression through STAT3 activation in a Rho-dependent manner

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Respiratory Research

ISSN: 1465-993X

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