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Fig. 9 | Respiratory Research

Fig. 9

From: Increased expression of TROP2 in airway basal cells potentially contributes to airway remodeling in chronic obstructive pulmonary disease

Fig. 9

The effect of TROP2 expression on EMT-like changes in BCs. Western blot analysis was performed on cell lysates (40 μg) prepared from cells transfected with the pcDNA3.1 or the expression vector pcDNA3.1-TROP2 and control BCs. Blots were incubated with the antibodies as indicated with GAPDH used as the control for protein loading. Protein levels indicated were quantitated based on chemiluminescence. a The protein levels of the epithelial marker E-cadherin was significantly decreased in pcDNA3.1-TROP2-BCs (P < 0.01) whereas the expression of the mesenchymal marker vimentin was increased compared to control cells (P < 0.01). * P < 0.01 vs untransfected cells; # P < 0.01 vs pcDNA3.1-BCs. b Down-regulation of TROP2 significantly increased E-cadherin expression and decreased vimentin expression in COPD-derived BCs (P < 0.01). * P < 0.01 vs untransfected cells; # P < 0.01 vs Scrambled-BCs

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Respiratory Research

ISSN: 1465-993X

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