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Fig. 3 | Respiratory Research

Fig. 3

From: Increased expression of TROP2 in airway basal cells potentially contributes to airway remodeling in chronic obstructive pulmonary disease

Fig. 3

Expression of TROP2 correlates with proliferative index of airway epithelium based on Ki67. a Immunohistochemistry detecting Ki67 expression in sections of paraffin embedded lung tissues from patients as indicated. Positive staining for Ki67 correlates with the brown staining from DAB. Original × 200; scale bars = 50 μm. b Quantitation of immunostaining for Ki67 in patient samples (n = 72) as indicated. The density of Ki67 positive cells was significantly higher in hyperplasic epithelium of COPD patients than in normal airway epithelium (P < 0.01). c Correlation of the level of TROP2 protein expression with Ki67 in COPD patient samples as determined by immunohistochemistry. Results indicated a positive correlation between increased TROP2 and Ki67 positive cells. * P < 0.01 vs non-smokers; # P < 0.01 vs smokers without COPD

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Respiratory Research

ISSN: 1465-993X

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