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Table 3 Flow cytometry absolute number of cells results from COPD patients susceptible to frequent vs. infrequent exacerbations

From: Differences in systemic adaptive immunity contribute to the ‘frequent exacerbator’ COPD phenotype

Cell type FE (n = 8) Mean abs No. ± SD/Median abs No. (IQR) *10^6/ml IE (n = 16) Mean abs No. ± SD/Median abs No. (IQR) *10^6/ml p
CD3+ 1.33 ± 0.38 1.42 ± 0.53 0.665
 CD4+ 0.91 ± 0.19 1.07 ± 0.42 0.223
  CD4+ HLA-DR+ 0.05 (0.02–0.07) 0.03 (0.02–0.04) 0.490
  CD4+ PD-1+ 0.27 ± 0.09 0.28 ± 0.14 0.785
  CD4+ Naive 0.34 ± 0.12 0.38 ± 0.21 0.505
  CD4+ Tcm 0.17 ± 0.05 0.25 ± 0.12 0.035
  CD4+ Tem 0.23 ± 0.12 0.26 ± 0.14 0.669
   CD4+ Tem PD-1+ 0.14 ± 0.07 0.13 ± 0.07 0.666
  CD4+ End 0.17 ± 0.06 0.17 ± 0.11 0.826
 CD8+ 0.28 (0.13–53) 0.30 (0.13–0.40) 0.697
  CD8+ HLA-DR+ 0.05 (0.01–0.09) 0.03 (0.01–0.06) 0.653
  CD8+ PD-1+ 0.12 ± 0.09 0.11 ± 0.07 0.707
  CD8+ Naïve 0.04 ± 0.02 0.04 ± 0.03 0.662
  CD8+ Tcm 0.05 (0.02–0.06) 0.04 (0.02–0.07) 0.976
  CD8+ Tem 0.16 ± 0.12 0.11 ± 0.07 0.368
   CD8+ Tem HLA-DR+ 0.02 ± 0.01 0.03 ± 0.06 0.759
  CD8+ End 0.13 ± 0.05 0.09 ± 0.06 0.575
 Treg 0.06 ± 0.03 0.08 ± 0.04 0.173
  Treg PD-1+ 0.02 ± 0.01 0.03 ± 0.01 0.296
NK 0.51 ± 0.24 0.30 ± 0.17 0.336
 NK CD56bright 0.01 ± <0.01 0.01 ± <0.01 0.572
 NK CD56dim 0.39 ± 0.12 0.18 ± 0.14 0.373
 NK CD56brightCD16dim 0.01 (<0.01–0.02) 0.01 (<0.01–0.01) 0.490
 NK CD56dimCD16bright 0.35 ± 0.14 0.15 ± 0.13 0.398
  NK CD56 + CD56bright 0.02 (0.01–0.03) 0.01 (<0.01–0.02) 0.653
  NK CD56 + CD56dim 0.29 (0.21–0.49) 0.26 (0.12 0.41) 0.490
iNKT 0.02 (0.01–0.03) 0.01 (0.01–0.03) 0.214
γδ T 0.01 (<0.01–0.02) <0.01 (<0.01–0.01) 0.153
 γδ T CD56+ 0.01 ± 0.01 0.01 ± 0.01 0.544
  1. Table shows the absolute number of cells in 1 ml of peripheral blood. Significance was calculated using t test or Mann-Whitney U test as appropriate. Abs No. absolute number, PD-1+ cell marker for programmed cell death, End end-stage T cell, Treg regulatory T cell, NK natural killer, iNKT invariant natural killer T cell