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Fig. 5 | Respiratory Research

Fig. 5

From: N-methyl-D-aspartate receptor activation mediates lung fibroblast proliferation and differentiation in hyperoxia-induced chronic lung disease in newborn rats

Fig. 5

NMDAR activation upregulate lung fibroblasts α-SMA and collagen expression in hyperoxia exposure newborn rat. The protein levels (A a-b) and gene expression of α-SMA (A c) were significantly higher in cells stimulated with hyperoxia (P < 0.01) in newborn rat lung fibroblasts. The protein levels (B a) and gene expression of type I (pro) collagen (B b) were also higher in cells stimulated with hyperoxia (P < 0.01). Treatment with NMDAR antagonist MK-801 inhibited these changes (P < 0.01). PCI: type I procollagen. H: hyperoxia group; C: control group; M: air + MK-801 group; HM: hyperoxia + mk-801 group. **P <0.01 vs. air group, †† P < 0.05 vs. hyperoxia group, n = 6 per group

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Respiratory Research

ISSN: 1465-993X

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