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Table 1 Hemodynamics and echocardiography data at 28 day after MCT injection

From: Lung-specific RNA interference of coupling factor 6, a novel peptide, attenuates pulmonary arterial hypertension in rats

Parameters Sham Vehicle −2w-MCT −2w-shRNA 2w-MCT 2w-shRNA
No. of surviving rats 20 19 18 18 17 16
Body weight, g 360 ± 8 296 ± 5* 291 ± 6* 335 ± 7*,** 286 ± 7* 323 ± 6*,**
Heart Rate, bpm 418 ± 12 420 ± 16 425 ± 14 422 ± 15 428 ± 16 426 ± 15
Cardiac Output (ml/min) 134 ± 2.3 107 ± 4* 107 ± 4* 116 ± 3.4* 109 ± 4.2* 112 ± 2.8*
Ejection Fraction (%) 66.8 ± 4.2 48.7 ± 4.6* 46.8 ± 3.9* 67.2 ± 5.3** 47.6 ± 4.3* 64.5 ± 3.4**
Pulmonary artery , cm 0.295 ± 0.01 0.41 ± 0.025* 0.38 ± 0.03* 0.317 ± 0.03** 0.42 ± 0.04* 0.336 ± 0.02**
Mean blood pressure 92.5 ± 3.2 88.5 ± 4.7 89.6 ± 3 90.8 ± 2.5 87.4 ± 3.2 88.3 ± 3.6
RV/BW (mg/g) 3.7 ± 0.2 10 ± 0.9* 9.7 ± 1* 5.6 ± 0.8*,** 9.4 ± 0.9* 6.2 ± 0.7*,**
RV wall thickness, cm 0.12 ± 0.01 0.21 ± 0.03* 0.21 ± 0.04* 0.13 ± 0.03** 0.22 ± 0.03* 0.16 ± 0.02**
RV area, mm2 11.7 ± 0.3 22 ± 0.7* 21.5 ± 0.6* 12.5 ± 0.5** 21 ± 0.4* 14.6 ± 0.4*,**
LV area, mm2 22.1 ± 0.4 22.5 ± 0.5 22.4 ± 0.4 22.3 ± 0.7 22.6 ± 0.5 22.4 ± 0.6
  1. RV right ventricle, LV left ventricle, BW body weight. All values are mean ± SD
  2. *p <0.05 compared with sham group
  3. **p < 0.05 compared with respective control MCT group