Table 1 Hemodynamics and echocardiography data at 28 day after MCT injection

No. of surviving rats

20

19

18

18

17

16

Body weight, g

360 ± 8

296 ± 5*

291 ± 6*

335 ± 7*,**

286 ± 7*

323 ± 6*,**

Heart Rate, bpm

418 ± 12

420 ± 16

425 ± 14

422 ± 15

428 ± 16

426 ± 15

Cardiac Output (ml/min)

134 ± 2.3

107 ± 4*

107 ± 4*

116 ± 3.4*

109 ± 4.2*

112 ± 2.8*

Ejection Fraction (%)

66.8 ± 4.2

48.7 ± 4.6*

46.8 ± 3.9*

67.2 ± 5.3**

47.6 ± 4.3*

64.5 ± 3.4**

Pulmonary artery , cm

0.295 ± 0.01

0.41 ± 0.025*

0.38 ± 0.03*

0.317 ± 0.03**

0.42 ± 0.04*

0.336 ± 0.02**

Mean blood pressure

92.5 ± 3.2

88.5 ± 4.7

89.6 ± 3

90.8 ± 2.5

87.4 ± 3.2

88.3 ± 3.6

RV/BW (mg/g)

3.7 ± 0.2

10 ± 0.9*

9.7 ± 1*

5.6 ± 0.8*,**

9.4 ± 0.9*

6.2 ± 0.7*,**

RV wall thickness, cm

0.12 ± 0.01

0.21 ± 0.03*

0.21 ± 0.04*

0.13 ± 0.03**

0.22 ± 0.03*

0.16 ± 0.02**

RV area, mm²

11.7 ± 0.3

22 ± 0.7*

21.5 ± 0.6*

12.5 ± 0.5**

21 ± 0.4*

14.6 ± 0.4*,**

LV area, mm²

22.1 ± 0.4

22.5 ± 0.5

22.4 ± 0.4

22.3 ± 0.7

22.6 ± 0.5

22.4 ± 0.6