Skip to main content

Table 3 Cox analysis for risk factors for an acute exacerbation of idiopathic pulmonary fibrosis

From: Risk factors for an acute exacerbation of idiopathic pulmonary fibrosis

  HR (95 % CI) P Value
Treatment after the diagnosis
Immunosuppressive agent
 Unadjusted 3.35 (1.27 to 8.84) 0.014
Cardiovascular diseases
 Unadjusted 2.49 (1.00 to 6.19) 0.049
 Adjusteda 3.21 (1.24 to 8.32) 0.016
GAP stage (≥II)
 Unadjusted 3.88 (1.54 to 9.80) 0.004
 Adjusteda 3.23 (1.22 to 8.51) 0.018
Serum markers
LDH, U/L, Cut off point = 180
 Unadjusted 4.00 (0.92 to 17.46) 0.065
 Adjusteda 3.49 (0.78 to 15.57) 0.101
KL-6, U/mL, Cut off point = 946
 Unadjusted 1.57 (0.67 to 3.68) 0.296
 Adjusteda 1.53 (0.65 to 3.59) 0.326
SP-D, ng/mL, Cut off point = 194.7
 Unadjusted 3.17 (1.21 to 8.31) 0.019
 Adjusteda 2.69 (0.98 to 7.42) 0.056
BAL fluid findings
Lymphocytes, %, Cut off point = 10.15
 Unadjusted 2.01 (0.89 to 4.52) 0.091
 Adjusteda 2.03 (0.90 to 4.57) 0.087
Neutrophils, %, Cut off point = 1.77
 Unadjusted 4.04 (0.92 to 17.79) 0.065
 Adjusteda 3.54 (0.79 to 15.94) 0.100
Eosinophils, %, Cut off point = 3.21
 Unadjusted 3.27 (1.29 to 8.29) 0.013
 Adjusteda 2.89 (1.11 to 7.51) 0.029
  1. Abbreviations: HR hazard ratio, CI confidence interval, GAP gender-age-physiology, LDH lactate dehydrogenase, KL-6 Krebs von den Lungen-6, SP-D surfactant protein-D, BAL bronchoalveolar lavage
  2. aAdjusted for immunosuppressive agent therapy
\