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Fig. 6 | Respiratory Research

Fig. 6

From: Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways

Fig. 6

Effect of neuropeptide receptor antagonists on the anti-IAV activities of SLIGRL-amide in mouse isolated tracheal segments by immunohistochemical staining of IAV nucleoprotein. Levels of staining for immunoreactive-IAV in the epithelium of perfused trachea exposed to IAV in the absence or presence of single acute dose of (a) capsaicin (10 μM), (b) substance P (1 μM) or (c) CGRP (1 μM) (n = 3-15 trachea). Also shown are the effects produced by an NK1 receptor antagonist (20 μM RP67580; b) and a CGRP receptor antagonist (10 μM CGRP8-37; c) on the anti-IAV activity of SLIGRL-amide. Shown are mean levels of immunoreactive IAV staining (and standard error of the mean), expressed as % of strong positive pixels, as outlined in the Methods section. *, indicates P <0.05, compared to respective IAV + saline control (one-way ANOVA)

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Respiratory Research

ISSN: 1465-993X

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