Table 1 Main characteristics of the healthy volunteers and the ARDS patients at the time of the VOT
From: Microvascular reactivity is altered early in patients with acute respiratory distress syndrome
VARIABLE | Volunteers (n = 27) | ARDS | ||
|---|---|---|---|---|
Total (n = 32) | Good evolution (n = 16) | Poor evolution (n = 16) | ||
Age (years) | 30 (27–31)* | 63 (48–71) | 68 (46–78) | 61 (51–66) |
Male n(%) | 15 (56) | 21 (66) | 12 (75) | 9 (56) |
Body mass index (Kg/m2) | 23 (22–25)* | 26 (23–29) | 25 (24–28) | 27 (22–30) |
Mean arterial pressure (mmHg) | 88 (83–91) | 82 (75–89) | 83 (80–93) | 78 (72–87) |
Heart rate (bpm) | 74 (70–79)* | 95 (81–104) | 96 (81–105) | 95 (83–102) |
Respiratory rate (bpm) | 12 (12–13)* | 24 (19–30) | 23 (18–30) | 24 (20–31) |
SpO2 | 98 (98–99)* | 97 (95–99) | 97 (95–99) | 98 (96–99) |
Hemoglobin O2 saturation (%) | - | 97 (95–99) | 97 (95–99) | 98 (96–100) |
Temperature (°C) | - | 37.0 (36.3-37.5) | 37.1 (36.6-37.6) | 36.7 (36.1-37.2) |
Sepsis n(%) | - | 16 (50) | 7 (44) | 9 (56) |
Primary ARDS n(%) | - | 9 (28) | 5 (31) | 4 (25) |
Trauma n(%) | - | 4 (13) | 2 (13) | 2 (13) |
Surgery n(%) | - | 18 (56) | 12 (75) | 6 (38) |
Chronic lung disease n(%) | - | 5 (16) | 1 (6) | 4 (25) |
Inspired O2 fraction (%) | - | 50 (40–55) | 50 (33–50) | 50 (40–70) |
Positive end-expiratory pressure (cmH20) | - | 6 (5–8) | 7 (6–8) | 5 (5–11) |
PaO2/FiO2 ratio | - | 172 (126–231) | 181 (126–243) | 172 (128–223) |
pH | - | 7.39 (7.34-7.44) | 7.40 (7.34-7.44) | 7.38 (7.33-7.45) |
PCO2 (mmHg) | - | 37 (36–44) | 37 (36–43) | 38 (35–53) |
Lactate (mmol/L) | - | 1.4 (0.8-2.5) | 1.4 (0.8-3.2) | 1.5 (0.9-2.3) |
Creatinine (mg/dL) | - | 1.1 (0.7-1.6) | 1.1 (0.8-1.4) | 1.0 (0.6-2.0) |
Renal replacement therapy n(%) | - | 4 (13) | 1 (6) | 3 (19) |
Total bilirubin (mg/dL) | - | 0.7 (0.5-1.1) | 0.6 (0.5-1.1) | 0.8 (0.6-1.3) |
Platelets (x103/μL) | - | 129 (91–197) | 143 (84–226) | 121 (95–192) |
Leukocytes (cells x103/μL) | - | 13.0 (9.4-16.7) | 13.9 (11.9-16.2) | 11.7 (7.6-17.9) |
Hemoglobin (mg/dL) | - | 9.6 (8.9-11.2) | 9.6 (9.0-10.8) | 9.7 (8.6-11.5) |
Sedation n(%) | - | 19 (59) | 8 (50) | 11 (69) |
APACHE II score | - | 22 (19–26) | 21 (18–23) | 25 (21–28)** |
SOFA score | - | 9 (7–13) | 8 (5–11) | 11 (7–15) |
Norepinephrine (mcg/Kg/min) | - | 0.01 (0.00-0.17) | 0.00 (0.00-0.05) | 0.07 (0.00-0.27) |
Dobutamine (mcg/Kg/min) | - | 0 (0–3) | 0 (0–2) | 0 (0–5) |
ICU length of stay (days) | - | 7.7 (4.4-13.7) | 6.0 (4.0-7.7) | 11.9 (7.3-20.6)** |
Ventilator free days at 28 days (days) | - | 21 (0–25) | 25 (24–26) | 0 (0–17)** |
Mortality n(%) | - | 8 (25) | 0 (0) | 8 (50)** |