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Table 1 Main characteristics of the healthy volunteers and the ARDS patients at the time of the VOT

From: Microvascular reactivity is altered early in patients with acute respiratory distress syndrome

VARIABLE Volunteers (n = 27) ARDS
Total (n = 32) Good evolution (n = 16) Poor evolution (n = 16)
Age (years) 30 (27–31)* 63 (48–71) 68 (46–78) 61 (51–66)
Male n(%) 15 (56) 21 (66) 12 (75) 9 (56)
Body mass index (Kg/m2) 23 (22–25)* 26 (23–29) 25 (24–28) 27 (22–30)
Mean arterial pressure (mmHg) 88 (83–91) 82 (75–89) 83 (80–93) 78 (72–87)
Heart rate (bpm) 74 (70–79)* 95 (81–104) 96 (81–105) 95 (83–102)
Respiratory rate (bpm) 12 (12–13)* 24 (19–30) 23 (18–30) 24 (20–31)
SpO2 98 (98–99)* 97 (95–99) 97 (95–99) 98 (96–99)
Hemoglobin O2 saturation (%) - 97 (95–99) 97 (95–99) 98 (96–100)
Temperature (°C) - 37.0 (36.3-37.5) 37.1 (36.6-37.6) 36.7 (36.1-37.2)
Sepsis n(%) - 16 (50) 7 (44) 9 (56)
Primary ARDS n(%) - 9 (28) 5 (31) 4 (25)
Trauma n(%) - 4 (13) 2 (13) 2 (13)
Surgery n(%) - 18 (56) 12 (75) 6 (38)
Chronic lung disease n(%) - 5 (16) 1 (6) 4 (25)
Inspired O2 fraction (%) - 50 (40–55) 50 (33–50) 50 (40–70)
Positive end-expiratory pressure (cmH20) - 6 (5–8) 7 (6–8) 5 (5–11)
PaO2/FiO2 ratio - 172 (126–231) 181 (126–243) 172 (128–223)
pH - 7.39 (7.34-7.44) 7.40 (7.34-7.44) 7.38 (7.33-7.45)
PCO2 (mmHg) - 37 (36–44) 37 (36–43) 38 (35–53)
Lactate (mmol/L) - 1.4 (0.8-2.5) 1.4 (0.8-3.2) 1.5 (0.9-2.3)
Creatinine (mg/dL) - 1.1 (0.7-1.6) 1.1 (0.8-1.4) 1.0 (0.6-2.0)
Renal replacement therapy n(%) - 4 (13) 1 (6) 3 (19)
Total bilirubin (mg/dL) - 0.7 (0.5-1.1) 0.6 (0.5-1.1) 0.8 (0.6-1.3)
Platelets (x103/μL) - 129 (91–197) 143 (84–226) 121 (95–192)
Leukocytes (cells x103/μL) - 13.0 (9.4-16.7) 13.9 (11.9-16.2) 11.7 (7.6-17.9)
Hemoglobin (mg/dL) - 9.6 (8.9-11.2) 9.6 (9.0-10.8) 9.7 (8.6-11.5)
Sedation n(%) - 19 (59) 8 (50) 11 (69)
APACHE II score - 22 (19–26) 21 (18–23) 25 (21–28)**
SOFA score - 9 (7–13) 8 (5–11) 11 (7–15)
Norepinephrine (mcg/Kg/min) - 0.01 (0.00-0.17) 0.00 (0.00-0.05) 0.07 (0.00-0.27)
Dobutamine (mcg/Kg/min) - 0 (0–3) 0 (0–2) 0 (0–5)
ICU length of stay (days) - 7.7 (4.4-13.7) 6.0 (4.0-7.7) 11.9 (7.3-20.6)**
Ventilator free days at 28 days (days) - 21 (0–25) 25 (24–26) 0 (0–17)**
Mortality n(%) - 8 (25) 0 (0) 8 (50)**
  1. *significant difference at the p <0.05 level versus ARDS patients; **significant difference at the p <0.05 level versus good evolution