Fig. 3
From: Protein tyrosine phosphatase PTP-RR regulates corticosteroid sensitivity
Regulation of PP2A by PTP-RR. a U937 cells exposed to IL-2/IL-4 for 48 h (or were not treated; NT). PP2AC was detected in PTP-RR-immunoprecipitates. b, c, d, PP2AC-Tyr307 phosphorylation (b), PP2A activity (c) and PP2AC protein expression (d) were analyzed in U937 cells transfected with scramble control (SC) or PTP-RR siRNAs. e, f, In U937 cells transfected with scramble control (SC) or PP2A siRNAs, immunopurified PTP-RR activity (e) and PTP-RR protein expression (f) were analyzed. Data in (f) is expressed as fold change against SC. Values represent means of four (a, d and f) or three (b, c and e) experiments ± SEM. # P < .05, ## P < .01 (vs. non-treatment control; NT or SC)