Table 1 Baseline demographics and clinical characteristics of trial participants
From: Effect of tiotropium on night-time awakening and daily rescue medication use in patients with COPD
All patients | Night-time awakening at baseline | No night-time awakening at baseline | ||||
|---|---|---|---|---|---|---|
Tiotropium | Placebo | Tiotropium | Placebo | Tiotropium | Placebo | |
(n = 544) | (n = 357) | (n = 280) | (n = 179) | (n = 264) | (n = 178) | |
Age, years | 65.11 ± 8.50 | 65.30 ± 8.84 | 63.86 ± 8.68 | 63.56 ± 8.86 | 66.44 ± 8.12 | 67.05 ± 8.50 |
Male, n (%) | 363 (66.7) | 227 (63.6) | 186 (66.4) | 115 (64.2) | 177 (67.0) | 112 (62.9) |
Race, n (%) | ||||||
White | 518 (95.2) | 330 (92.4) | 263 (93.9) | 159 (88.8) | 255 (96.6) | 171 (96.1) |
Black | 26 (4.8) | 25 (7.0) | 17 (6.1) | 19 (10.6) | 9 (3.4) | 6 (3.4) |
Asian | 0 (0.0) | 2 (0.6) | 0 (0.0) | 1 (0.6) | 0 (0.0) | 1 (0.6) |
Body mass index, kg/m2 | 28.32 ± 5.66 | 28.07 ± 5.96 | 28.32 ± 5.58 | 27.59 ± 6.00 | 28.32 ± 5.77 | 28.55 ± 5.89 |
Alcohol use, n (%) | ||||||
Non-drinker | 284 (52.2) | 174 (48.7) | 152 (54.3) | 89 (49.7) | 132 (50.0) | 85 (47.8) |
Average consumption | 259 (47.6) | 181 (50.7) | 128 (45.7) | 89 (49.7) | 131 (49.6) | 92 (51.7) |
Excessive consumption | 1 (0.2) | 2 (0.6) | 0 (0.0) | 1 (0.6) | 1 (0.4) | 1 (0.6) |
Smoking history, pack-years | 62.59 ± 30.68 | 59.21 ± 30.53 | 64.31 ± 32.31 | 59.25 ± 31.41 | 60.77 ± 28.80 | 59.17 ± 29.72 |
Duration of COPD, years | 8.64 ± 7.42 | 8.05 ± 6.70 | 8.88 ± 7.56 | 8.64 ± 7.42 | 8.38 ± 7.28 | 7.47 ± 5.84 |
Rescue medication use/24 h | 3.66 ± 2.71 | 3.44 ± 2.57 | 4.30 ± 2.92 | 4.08 ± 2.77 | 2.99 ± 2.28 | 2.80 ± 2.18 |
FEV1, L | 1.05 ± 0.41 | 1.01 ± 0.44 | 1.05 ± 0.42 | 1.00 ± 0.42 | 1.05 ± 0.41 | 1.02 ± 0.46 |
FEV1, % predicted (Morris equation [11]) | 38.02 ± 14.07 | 37.44 ± 14.18 | 36.88 ± 13.75 | 36.36 ± 13.91 | 39.22 ± 14.32 | 38.53 ± 14.41 |
FEV1, % predicted (ECSC equation [13]) | 36.29 ± 13.48 | 35.74 ± 13.62 | 35.22 ± 13.20 | 34.75 ± 13.38 | 37.43 ± 13.71 | 36.75 ± 13.82 |
FVC, L | 2.31 ± 0.79 | 2.23 ± 0.78 | 2.28 ± 0.79 | 2.22 ± 0.78 | 2.35 ± 0.79 | 2.25 ± 0.78 |
FEV1/FVC, % | 45.96 ± 11.60 | 45.51 ± 11.70 | 46.59 ± 11.52 | 45.52 ± 11.93 | 45.30 ± 11.67 | 45.51 ± 11.49 |