Fig. 1

Adjusted weekly mean night-time awakening scores per night due to COPD symptoms. Data presented are for all patients and for the subgroups of patients who did and did not experience at least one night-time awakening due to COPD symptoms at baseline. Night-time awakening scores were based on the following: 0 for no awakenings; 1 for one awakening; 2 for two to three awakenings; and 3 for being awake for most of the night. Data are mean ± standard error. The means are adjusted for center effects and baseline. The overall mean is the average over the 13 on-treatment weekly means. There were no significant differences between tiotropium and placebo for the group of patients with no awakening at baseline at any time point. *p < 0.05; **p < 0.01; ***p < 0.001 for tiotropium versus placebo