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Table 3 Pneumothorax risk factors

From: Birt-Hogg-Dubé syndrome: a large single family cohort

Baseline characteristics OR SD P 95 % CI
Sex 0.40 0.30 0.23 0.09–1.76
Age 0.97 0.03 0.43 0.92–1.03
BMI 1.03 0.11 0.79 0.83–1.28
Height 0.97 0.05 0.67 0.88–1.07
Smoker 1.00 - - -
Smoking Pack years 1.18 0.14 0.15 0.94–1.47
Asthma 0.35 0.35 0.29 0.05–2.47
FEV1/FVC absolute 0.92 0.05 0.16 0.83–1.03
FEV1 % predicted 0.98 0.026 0.52 0.93–1.03
FVC % predicted 1.00 0.02 0.88 0.96–1.05
DLCO % predicted 0.98 0.017 0.24 0.95–1.01
Renal Cysts 1.33 1.23 0.75 0.22–8.22
Dermatologic findings 1.30 0.94 0.72 0.32–5.33
Cyst Number     
 Few (<5 cysts) 0.51 0.47 0.47 0.08–3.14
 Numerous (>5) 1.96 1.82 0.47 0.32–12.1
Cyst Size 3.23 1.44 0.008 1.35–7.73
 0–2.9 cm diameter 0.06 0.06 0.003 0.01–0.40
 3–10 cm diameter 15.4 14.3 0.003 2.49–95.1
Cyst Distribution 0.62 0.22 0.18 0.30–1.25
Extent of Upper Lung 1.75 1.12 0.38 0.50–6.15
Zone Disease (% volume affected by cysts)     
  < 25 % of UL 2.25 2.74 0.51 0.21–24.4
  > 25 % of UL 0.44 0.54 0.51 0.04–4.82
Extent of Lower Lung 6.43 4.96 0.016 1.41–29.2
Zone Disease (% volume affected by cysts)     
  < 25 % of LL 0.25 0.22 0.12 0.04–1.45
  > 25 % of LL 4.57 3.89 0.07 0.88–23.7
  1. Asthma was defined as full reversibility of airflow obstruction following bronchodilator administration or a positive methacholine challenge test
  2. Abbreviations: BMI body mass index, DLC O diffusing capacity for carbon monoxide, FEV 1 forced expiratory volume in one second, FVC forced vital capacity, UL upper lobe, LL lower lobe