| COPD | Smokers |
---|
| Interaction ratio IL-2 |
Dex (M) | 10−8
| 10−7
| 10−6
| 10−8
| 10−7
| 10−6
|
Io
| 57.3 | 69.9 | 81.1 | 64.0 | 78.1 | 83.8 |
IE
| 64.5 | 79.0 | 81.0 | 54.1 | 77.2 | 84.6 |
IR | 0.9 | 0.9 | 1.0 | 1.2 | 1.1 | 1.0 |
| Interaction ratio IFNγ |
Dex (M) | 10−8
| 10−7
| 10−6
| 10−8
| 10−7
| 10−6
|
Io
| 60.2 | 70.1 | 67.6 | 61.9 | 74.6 | 82.9 |
IE
| 50.7 | 70 | 71.9 | 44.4 | 70.4 | 77.2 |
IR | 1.2 | 1.0 | 0.9 | 1.4 | 1.1 | 1.1 |
- Data presented as percent inhibition relative to cells stimulated with anti-CD2/3/28 IO & IE. IR is the ratio of IO to IE. COPD: chronic obstructive pulmonary disease; Dex: dexamethasone; IL-2: interleukin 2; IFNγ: interferon gamma; IO: Observed inhibition; IE: Expected inhibition; IR: interaction ratio. An interaction ratio between 0.5 and 1.5 is consistent with additive effect