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Table 3 Interaction ratios for combination of dexamethasone and GSK256066 on pulmonary CD8 cells

From: Additive anti-inflammatory effects of corticosteroids and phosphodiesterase-4 inhibitors in COPD CD8 cells

  COPD Smokers
  Interaction ratio IL-2
Dex (M) 10−8 10−7 10−6 10−8 10−7 10−6
Io 57.3 69.9 81.1 64.0 78.1 83.8
IE 64.5 79.0 81.0 54.1 77.2 84.6
IR 0.9 0.9 1.0 1.2 1.1 1.0
  Interaction ratio IFNγ
Dex (M) 10−8 10−7 10−6 10−8 10−7 10−6
Io 60.2 70.1 67.6 61.9 74.6 82.9
IE 50.7 70 71.9 44.4 70.4 77.2
IR 1.2 1.0 0.9 1.4 1.1 1.1
  1. Data presented as percent inhibition relative to cells stimulated with anti-CD2/3/28 IO & IE. IR is the ratio of IO to IE. COPD: chronic obstructive pulmonary disease; Dex: dexamethasone; IL-2: interleukin 2; IFNγ: interferon gamma; IO: Observed inhibition; IE: Expected inhibition; IR: interaction ratio. An interaction ratio between 0.5 and 1.5 is consistent with additive effect