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Table 3 Interaction ratios for combination of dexamethasone and GSK256066 on pulmonary CD8 cells

From: Additive anti-inflammatory effects of corticosteroids and phosphodiesterase-4 inhibitors in COPD CD8 cells

 

COPD

Smokers

 

Interaction ratio IL-2

Dex (M)

10−8

10−7

10−6

10−8

10−7

10−6

Io

57.3

69.9

81.1

64.0

78.1

83.8

IE

64.5

79.0

81.0

54.1

77.2

84.6

IR

0.9

0.9

1.0

1.2

1.1

1.0

 

Interaction ratio IFNγ

Dex (M)

10−8

10−7

10−6

10−8

10−7

10−6

Io

60.2

70.1

67.6

61.9

74.6

82.9

IE

50.7

70

71.9

44.4

70.4

77.2

IR

1.2

1.0

0.9

1.4

1.1

1.1

  1. Data presented as percent inhibition relative to cells stimulated with anti-CD2/3/28 IO & IE. IR is the ratio of IO to IE. COPD: chronic obstructive pulmonary disease; Dex: dexamethasone; IL-2: interleukin 2; IFNγ: interferon gamma; IO: Observed inhibition; IE: Expected inhibition; IR: interaction ratio. An interaction ratio between 0.5 and 1.5 is consistent with additive effect