Skip to main content
Fig. 2 | Respiratory Research

Fig. 2

From: Additive anti-inflammatory effects of corticosteroids and phosphodiesterase-4 inhibitors in COPD CD8 cells

Fig. 2

The effect of PDE4 inhibitors with dexamethasone on IFNγ release from peripheral blood CD8 cells and PBMCs. Peripheral blood CD8 cells and PBMCs from COPD (n = 13, a & b), Smoker (n = 8 c & d) and Healthy non-smokers (HNS,n = 7, e & f) were pre-treated for 1 h with various concentrations of dexamethasone (Dex) alone (О) or in combination with GSK256066 (■), Roflumilast (♦) or Forskolin (▲). The effect of GSK256066, roflumilast and forskolin alone is represented as log[Dex]M = 0. Cells were stimulated for 24 h with anti-CD2/3/28 beads. Supernatants were harvested and Interferon gamma (IFNγ) was measured by ELISA. Data presented as mean ± SE

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us