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Fig. 1 | Respiratory Research

Fig. 1

From: Additive anti-inflammatory effects of corticosteroids and phosphodiesterase-4 inhibitors in COPD CD8 cells

Fig. 1

The effect of PDE4 inhibitors with dexamethasone on IL-2 release from peripheral blood CD8 cells and PBMCs. Peripheral blood CD8 cells and PBMCs from COPD (n = 13, a & b), Smoker (n = 8, c & d) and Healthy non-smokers (HNS, n = 7 e & f) were pre-treated for 1 h with various concentrations of dexamethasone (Dex) alone (О) or in combination with GSK256066 (■), Roflumilast (♦) or Forskolin (▲). The effect of GSK256066, roflumilast and forskolin alone is represented as log[Dex] = 0. Cells were stimulated for 24 h with anti-CD2/3/28 beads. Supernatants were harvested and Interleukin 2 (IL-2) was measured by ELISA. Data presented as mean ± SE

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Respiratory Research

ISSN: 1465-993X

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