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Table 1 Characteristics of the subjects in the lung tissue study

From: Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease

  Control never-smokers Control ex-smokers COPD ex-smokers
Subjects n 23 17 24
Male sex, % 30.4 82.4 87.5
Age, y 66.3 ± 9 65.3 ± 10 70.8 ± 7
Smoking status, pack-y 0 42.2 ± 20 49.0 ± 28
FEV1, L 2.41 ± 0.60 2.55 ± 0.47 1.83 ± 0.53**
FEV1 %predicted, % 112 ± 16 92.5 ± 8.0* 72.7 ± 18*, **
FVC, L 3.05 ± 0.72 3.35 ± 0.66* 3.04 ± 0.74**
FVC %predicted, % 114 ± 15 98.8 ± 9.0 96.8 ± 17*
FEV1/FVC, % 79.2 ± 4.4 76.3 ± 4.1 59.6 ± 8.3*, **
DLCO/VA %predicted, %a 96.1 ± 14 89.7 ± 15 79.9 ± 22*
  1. Data are presented as mean ± SD. FEV1 = forced expiratory volume in 1 s; FVC = forced vital capacity; DLCO = diffusing capacity of the lung for carbon monoxide; VA = alveolar volume
  2. a:DLCO/VA are 23 healthy never-smokers, 16 healthy ex-smokers, and 22 COPD ex-smokers. *: p < 0.05 compared to control never smokers. **: p < 0.05 compared to control ex-smokers