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Fig. 6 | Respiratory Research

Fig. 6

From: TNF-α and IL-1β-activated human mesenchymal stromal cells increase airway epithelial wound healing in vitro via activation of the epidermal growth factor receptor

Fig. 6

Proposed model of enhanced wound closure in airway epithelial cells by MSC-CMSTIM. In MSCs, exposure to TNF-α and IL-1β increases the mRNA expression of various growth factors. Conditioned medium from these MSCs contributes to wound healing of airway epithelial cells via three mechanisms: direct activation of EGFR; activation of matrix metalloproteases which results in shedding of membrane bound EGFR ligands; induction of mRNA expression of EGFR ligands by the airway epithelium. Activation of the downstream MAP kinase ERK1/2, which is known as a regulator of cell proliferation (a.o. assessed by increased Cyclin D1) and differentiation, subsequently results in increased wound healing

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Respiratory Research

ISSN: 1465-993X

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