Fig. 4

YKL-40 expression and protein secretion is inhibited by dexamethasone. YKL-40 mRNA levels (normalized expression) and YKL-40 protein secretion (a and b, respectively) in MΦ1 and MΦ2 with addition of dexamethasone at day 0, 3 and 7 of differentiation (0.1, 0.3 and 1nM) (left, middle and right panel, respectively). LL-37 mRNA levels (normalized expression) after 0, 3 and 7 days of differentiation with dexamethasone (0.1, 0.3 and 1nM) (c left, middle and right panel, respectively). Data represent means and SEM (n = 3 donors). * p ≤ 0.05, ** p < 0.01 or *** p < 0.001 compared to MΦ2 with corresponding stimulus. $ = p ≤ 0.05, $$ p < 0.01 or $$$ p < 0.001 compared to corresponding unstimulated cells. ##: p < 0.01 or ### p < 0.001 compared to corresponding LPS stimulated cells