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Fig. 2 | Respiratory Research

Fig. 2

From: Prostaglandin E2 stimulates normal bronchial epithelial cell growth through induction of c-Jun and PDK1, a kinase implicated in oncogenesis

Fig. 2

EP4 Mediates the Cell Proliferation and increased expression and activation of PDK1 induced by PGE2 in HBEc14-KT and BEAS2B cells. a EP4 antagonist AH23848 decreased the cell proliferation induced by dmPGE2 in normal bronchial epithelial cells. b EP4 siRNA decreases the cell proliferation induced by dmPGE2 in normal bronchial epithelial cells. c EP4 antagonist AH23848 decreased the phosphorylation and expression of PDK1 induced by dmPGE2 in BEAS2B and HBEc14-KT cells. d EP4 siRNA decreased the phosphorylation and expression of PDK1 induced by dmPGE2 in BEAS2B and HBEc14-KT cells. e Effect on PDK1 promoter activity

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Respiratory Research

ISSN: 1465-993X

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