|
N
|
30
|
52
|
55
|
51
| |
|
Pre-BD FEV1 (L)
|
3.98 (0.81) *
|
3.35 (0.81)
|
2.39 (0.62)
|
2.10 (0.71)
|
<0.0001
|
|
Pre-BD FEV1 (% predicted normal)
|
103.3 (13.4)
|
92.7 (14.3)
|
73.6 (10.4)
|
65.4 (12.7)
|
<0.0001
|
|
Post-BD FEV1 (L)
|
4.10 (0.84)
|
3.61 (0.87)
|
2.67 (0.66)
|
2.43 (0.81)
|
<0.0001
|
|
Post-BD FEV1 (% predicted normal)
|
106.2 (13.7)
|
101.4 (14.0)
|
82.7 (10.2)
|
75.7 (15.4)
|
<0.0001
|
|
Pre-BD FEV/FVC ratio
|
0.83 (0.06)
|
0.77 (0.08)
|
0.66 (0.09)
|
0.61 (0.09)
|
<0.0001
|
|
Post-BD FVC (% predicted normal)
|
103.8 (15.9)
|
105.0 (15.5)
|
96.4 (11.4)
|
94.0 (15.1)
|
0.0004
|
|
BDR (%)
|
2.9 (4.1)
|
8.5 (8.3)
|
15.2 (10.3)
|
18.3 (14.5)
|
0.0016
|
|
BDR (mL)
|
114.8 (140.6)
|
265.1 (231.7)
|
335.2 (234.3)
|
355.7 (270.6)
|
0.45
|
|
PC20 methacholine (mg/mL)
|
NA
|
1.68 (+10.85/-0.26)**
|
0.93 (+6.49/-0.13)**
|
0.63 (+2.62/-0.15)**
|
0.034
|
|
ACQ7
|
NA
|
0.84 (0.69)
|
1.33 (0.71)
|
1.92 (1.01)
|
<0.0001
|
|
Controlled ACQ <0.75 (N, %)
|
NA
|
29 (56 %)
|
10 (18 %)
|
4 (8 %)
| |
|
Partially controlled ACQ 0.75-1.5 (N, %)
|
NA
|
13 (25 %)
|
24 (44 %)
|
16 (31 %)
|
<0.0001
|
|
Uncontrolled ACQ ≥ 1.5 (N, %)
|
NA
|
10 (19 %)
|
21 (38 %)
|
31 (61 %)
| |
|
AQLQ
|
NA
|
5.86 (0.93)
|
5.68 (1.11)
|
5.09 (1.28)
|
0.0016
|
