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Fig. 7 | Respiratory Research

Fig. 7

From: Activation of Src-dependent Smad3 signaling mediates the neutrophilic inflammation and oxidative stress in hyperoxia-augmented ventilator-induced lung injury

Fig. 7

Schematic figure illustrating the signaling pathway activation with high-tidal-volume mechanical ventilation and hyperoxia. Hyperoxia-induced augmentation of mechanical stretch-mediated cytokine production and lung injury were attenuated with Src-deficient mice and pharmacological inhibition of Smad3 activity by SIS. MIP-2 = macrophage inflammatory protein-2; MMP-9 = matrix metalloproteinase-9; SIS3 = specific inhibitor of Smad3; Src+/− = Src-deficient mice; VILI = ventilator-induced lung injury

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Respiratory Research

ISSN: 1465-993X

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