Inhaled carbon monoxide protects time-dependently from loss of hypoxic pulmonary vasoconstriction in endotoxemic mice

Table 1 Serum concentration of cytokines (in pg/ml) 18 h after LPS-challenge

Cytokines	(saline/air 18 h)	(LPS/air 18 h)	(saline/CO 18 h)	(LPS/CO 18 h)
IL-1β	6.7 ± 6.1⁽³⁾	923 ± 512	19.8 ± 8.6⁽²⁾	761 ± 302
IL-2	⁽⁰⁾	21.1 ± 7.6	⁽⁰⁾	24.7 ± 7.9
IL-4	0.9 ± 0.3⁽²⁾	9.4 ± 3.5	⁽⁰⁾	9.8 ± 4.0
IL-5	10.4⁽¹⁾	415 ± 140	8.3 ± 5.9⁽³⁾	449 ± 300
IL-6	45.6 ± 4.0⁽²⁾	1,041,394 ± 1,305,421	5.2⁽¹⁾	438,575 ± 120,555
IL-10	2.2 ⁽¹⁾	1744 ± 1074	6.2 ± 5.7⁽²⁾	748 ± 281
IL-12	14.0 ± 9.2	1787 ± 485	33.1 ± 19.0⁽²⁾	1948 ± 383
IL-13	27.8 ± 7.2⁽²⁾	987 ± 518	30.3 ± 15.2	917 ± 281
TNF-α	⁽⁰⁾	269 ± 106	⁽⁰⁾	246 ± 64.8
INF-γ	⁽⁰⁾	3039 ± 1819	⁽⁰⁾	10,039 ± 10,856
GM-CSF	⁽⁰⁾	338 ± 77,9	32.8⁽¹⁾	312 ± 50.7
MCP-1	17.4 ± 23.1⁽²⁾	122,499 ± 96,488	⁽⁰⁾	80,492 ± 29,767

Data are presented as mean ± SD; n = 4 per group; ⁽ⁿ⁾ = number of values within the detectable concentration range if n ≠ 4; ⁽⁰⁾ = all values were below the least detectable concentration

ISSN: 1465-993X