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Fig. 7 | Respiratory Research

Fig. 7

From: Inhaled carbon monoxide protects time-dependently from loss of hypoxic pulmonary vasoconstriction in endotoxemic mice

Fig. 7

Increase of lung mRNA of NOS-2, HO-1 and HO-2 after LPS challenge; a. Average values of increase of NOS-2 mRNA in lungs from saline treated controls (open bars) and LPS-treated mice (black bars) after exposure to air or to 50 ppm CO for 18 h. NOS-2 mRNA was increased in LPS-treated mice more than 50fold compared to controls, which was prevented by exposure to 50 ppm CO for 18 h; *p < 0.001 vs. (saline/air 18 h); # p < 0.05 vs. (LPS/CO 18 h). b. Average values of increase of HO-1 mRNA in lungs from saline treated controls (open bars) and LPS-treated mice (black bars) after exposure to air or to 50 ppm CO for 18 h. HO-1 mRNA was increased in LPS-treated mice compared to controls, which was prevented by exposure to 50 ppm CO for 18 h; *p < 0.05 vs. (saline/air 18 h). c. Average values of increase of HO-2 mRNA in lungs from saline treated controls (open bars) and LPS-treated mice (black bars) after exposure to air or to 50 ppm CO for 18 h. HO-2 mRNA was not increased in LPS-treated mice compared to controls, which was not altered by exposure to 50 ppm CO for 18 h. Data are presented as mean ± SD

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Respiratory Research

ISSN: 1465-993X

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