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Table 5 CT scan measurements of changes in volume, luminal area and airway wall thickness with sulforaphane (SF) treatment measured at either total lung capacity (TLC) or functional residual capacity (FRC) (mean ± SD)

From: Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways

  Before SF After SF p for SF effect
TLC lung volume (mL) 4175 4195 0.68
FRC lung volume (mL) 1470 1647 0.44
Mean lung density at TLC (HU) −820 ± 34 −823 ± 33 0.13
Air trapping (%) (FRC) 4.6 ± 8.3 7.9 ± 11.8 0.10
Airway luminal area (TLC) mm2 44.7 ± 10.3 45.1 ± 8.5 0.07
Large 103 ± 13 102.9 ± 16 0.73
Medium 30.9 ± 1.8 32 ± 4.5 0.04
Small 13.1 ± 1.6 14.3 ± 3.4 0.01
Airway wall thickness (fraction luminal diameter) (TLC) 0.57 ± 0.03 0.57 ± 0.02 0.82
Large 0.45 ± 0.02 0.46 ± 0.03 0.12
Medium 0.58 ± 0.02 0.58 ± 0.03 0.96
Small 0.67 ± 0.02 0.66 ± 0.04 0.03