Table 5 CT scan measurements of changes in volume, luminal area and airway wall thickness with sulforaphane (SF) treatment measured at either total lung capacity (TLC) or functional residual capacity (FRC) (mean ± SD)
| Â | Before SF | After SF | p for SF effect |
|---|---|---|---|
TLC lung volume (mL) | 4175 | 4195 | 0.68 |
FRC lung volume (mL) | 1470 | 1647 | 0.44 |
Mean lung density at TLC (HU) | −820 ± 34 | −823 ± 33 | 0.13 |
Air trapping (%) (FRC) | 4.6 ± 8.3 | 7.9 ± 11.8 | 0.10 |
Airway luminal area (TLC) mm2 | 44.7 ± 10.3 | 45.1 ± 8.5 | 0.07 |
Large | 103 ± 13 | 102.9 ± 16 | 0.73 |
Medium | 30.9 ± 1.8 | 32 ± 4.5 | 0.04 |
Small | 13.1 ± 1.6 | 14.3 ± 3.4 | 0.01 |
Airway wall thickness (fraction luminal diameter) (TLC) | 0.57 ± 0.03 | 0.57 ± 0.02 | 0.82 |
Large | 0.45 ± 0.02 | 0.46 ± 0.03 | 0.12 |
Medium | 0.58 ± 0.02 | 0.58 ± 0.03 | 0.96 |
Small | 0.67 ± 0.02 | 0.66 ± 0.04 | 0.03 |