Fig. 2
From: Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis
Expression and localization of FGF1 and FGF-receptors FGFR1, FGFR2, FGFR3 and FGFR4 in non-IPF, donor control lungs. Representative immunohistochemistry for FGF1 (a1), FGFR1, FGFR2, FGFR3, and pro-surfactant protein C (proSP-C) in serial sections of normal control-lung tissue. Alveolar epithelial type-II cells (AECII, indicated by arrows) of normal lungs do not express FGF1 (a1,2) and FGFR1 (a3,4), but indicate moderate expression of FGFR2 (a5,6) and robust expression of FGFR3 (a7,8), and FGFR4 (a9,10). Representative immunohistochemistry for FGF1, FGFR1, FGFR2, FGFR3, and alpha-smooth-muscle-actin (α-SMA) in serial sections of normal control-lung tissue. Vascular smooth muscle cells (upper and middle panels) showed strong expression of FGF1 (b2,8) and FGF-receptors FGFR1 (b3,9), FGFR2 (b4,10), FGFR3 (b5,11), and FGFR4 (b6,12). Scale bars: a1-10 (25 μm); b1-6 (250 μm), b7-12 (100 μm)