Association of 25-Hydroxyvitamin D status and genetic variation in the vitamin D metabolic pathway with FEV1 in the Framingham Heart Study

Table 1 Baseline¹ population characteristics of Framingham Heart Study participants

25(OH)D—FEV₁ Analyses	Offspring Cohort	Third Generation Cohort	P-value²
N in analysis	N = 1,435	N = 3,599
FEV₁, L	2.7 (0.8)	3.6 (0.8)	<0.0001
Follow-up duration, yr³	7.2 (1.9)	6.1 (0.6)	<0.0001
Baseline age, yr	59.9 (9.2)	40.2 (8.7)	<0.0001
Male, %	48	47	0.84
Height, cm	168.0 (9.1)	170.6 (9.3)	<0.0001
Baseline pack-years	26.0 (22.7)	13.7 (14.2)	<0.0001
Current smokers⁴, %	12.8	15.2	0.02
Former smokers⁴, %	50.8	27.0	<0.0001
BMI	28.0 (5.1)	26.9 (5.4)	<0.0001
25(OH)D, ng/ml⁵	18.0 (1.5)	34.5 (1.5)	<0.0001
N at risk of 25(OH)D deficiency (<12 ng/mL), %	207 (14.4 %)	44 (1.2 %)	<0.0001
N at risk of 25(OH)D inadequacy (<20 ng/mL), %	801 (55.8 %)	311 (8.6 %)	<0.0001

¹Baseline measurements are from the exam at time of vitamin D measurement (either Exam 6 or 7 for Offspring, and Exam 1 for Third Generation); Participant characteristics listed as mean (SD) for continuous variables and number (%) for categorical variables
² P-values for continuous variables calculated from unpaired t-test; P-values for categorical variables calculated from chi-square test
³Follow-up duration of spirometry measurements subsequent to serum 25(OH)D measurement; average duration calculated for N = 1,223 Offspring cohort participants with longitudinal spirometry and N = 2,894 Third Generation cohort participants
⁴Current smokers at baseline; former smokers at all time points
⁵Geometric mean of 25(OH)D

ISSN: 1465-993X