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Table 3 Biomarker levels at exacerbation and 4 weeks follow-up

From: Accelerated extracellular matrix turnover during exacerbations of COPD

 

Exacerbation (ng/ml)

Follow-up (ng/ml)

P value

C3M

29.24 [26.32–32.49]

22.64 [20.78–24.67]

<0.0001

C4M

95.96 [85.83–107.28]

73.30 [66.59–80.69]

<0.0001

C6M

19.78 [16.82–23.27]

13.27 [11.56–15.23]

<0.0001

ELM7

4.26 [3.90–4.64]

3.61 [3.37–3.87]

<0.0001

EL-NE

7.79 [6.30–9.63]

5.23 [4.41–6.21]

<0.0001

VCANM

1.69 [1.58–1.80]

1.87 [1.78–1.97]

0.0001

Pro-C3

12.10 [10.60–13.81]

12.79 [11.35–14.42]

0.2549

P4NP 7S

510.99 [440.91–592.21]

359.20 [312.28–413.17]

<0.0001

Pro-C6

5.36 [4.81–5.99]

6.38 [5.71–7.14]

<0.0001

  1. Results are presented as geometric mean [95 % confidence interval] and corresponding P values comparing circulating biomarker levels at time of exacerbation and follow-up