Table 2 Characteristics of subjects in the included studies of clinical phenotypes for COPD
From: Derivation and validation of clinical phenotypes for COPD: a systematic review
Study | Classification of patients based on GOLD stage, n (%) | FEV 1 (% predicted), mean (SD) § | Age, mean (SD) § | Proportion males (%) § | Smoking exposure, pack years, mean (SD) § | MMRC score, mean (SD) § |
|---|---|---|---|---|---|---|
Burgel et al. (2010) | GOLD 1 - 21 (6.5) GOLD 2 -135 (42) GOLD 3 -107 (33) GOLD 4 - 59 (18) | GOLD 1 - 85 (82-86) GOLD 2 - 65 (59-71) GOLD 3 - 40 (34-45) GOLD 4 - 25 (21-29) | GOLD 1 - 66 (58-75) GOLD 2 - 66 (58-72) GOLD 3 - 64 (57-73) GOLD 4 - 63 (58-72) | GOLD 1 - 71 GOLD 2 - 79 GOLD 3 - 71 GOLD 4 - 85 | GOLD 1 - 41 (28-56) GOLD 2 - 42 (26-55) GOLD 3 - 38 (25-50) GOLD 4 - 44 (30-72) | GOLD 1 - 1 (0-1) GOLD 2 - 1 (1-2) GOLD 3 - 2 (1-3) GOLD 4 - 3 (2-4) |
Burgel et al. (2012) | Same as above | Same as above | Same as above | Same as above | Same as above | Same as above |
Burgel et al. (2012) | GOLD 1 - 120 (22.8) GOLD 2 -169 (32.1) GOLD 3 -149 (28.3) GOLD 4 - 89 (16.9) | GOLD 1 - 93 (87-103) GOLD 2 - 64 (57-71) GOLD 3 - 40 (36-44) GOLD 4 - 24 (20-28) | GOLD 1 - 62 (58-67) GOLD 2 - 68 (61-74) GOLD 3 - 68 (62-75) GOLD 4 - 61 (58-65) | GOLD 1 - 80 GOLD 2 - 79 GOLD 3 - 78 GOLD 4 - 72 | GOLD 1 - 43 (32-55) GOLD 2 - 47 (34-61) GOLD 3 - 50 (32-64) GOLD 4 - 46 (33-60) | GOLD 1 - 0 (0-1) GOLD 2 - 1 (0-2) GOLD 3 - 2 (1-3) GOLD 4 - 3 (1-3) |
Cho et al. (2010) | Not reported. Only subjects with GOLD stages 3 and 4 included | 28.3 (7.33) | 67.4 (6.08) | 197 (64) | 67.4 (30.4) | Not reported |
DiSantostefano et al. (2013) | Not reported. Only subjects with pre-bronchodilator FEV1 ≤ 50% predicted included | 33.6 (25 – 41.9) | 65 (59-72) | 833 (54) | 52 (40-77), 633 (41%) current smokers | Not reported |
Garcia-Aymerich et al. (2011) | Not reported | 52.4 (16.2) | 67.9 (8.6) | 318 (93) | Not reported, 109 (32.9%) current smokers | 2 (2-3) |
Spinaci et al. (1985) | Not reported, all subjects had a FEV1/VC < 0.6 | FEV1/VC 41.06 (0.39) | 59.5 (9.8) | 398 (75) | Not reported, 274 (51.5%) current smokers | Not reported |
Vanfleteren et al. (2013) | Not reported. Only subjects with GOLD stages 2 – 4 included | 51.2 (16.9) | 63.6 (7) | 59 | 46 (26) | 2.1 (1.09) |