Table 1 Characteristics of the included studies of clinical phenotypes for COPD
From: Derivation and validation of clinical phenotypes for COPD: a systematic review
Study, country, period | Setting, design | Inclusion criteria | Number included in the analysis/ number eligible | Reason for exclusion | Difference between included and excluded patients |
|---|---|---|---|---|---|
Burgel et al. (2010), France, Jan 2005 - Aug 2008 | Pulmonary units in university hospitals, cross-sectional | Stable COPD§ | 322/584 (55%) | Missing/incomplete data | Significant difference in sex distribution |
Burgel et al. (2012), France, Jan 2005 - June 2009 | Pulmonary units in university hospitals, prospective cohort | Stable COPD§ | 303/584 (52%) | Missing/incomplete data | Significant difference in sex distribution |
Burgel et al. (2012), Belgium, Outcome assessed in Jan 2010 | 2 cohorts - Leuven university hospital COPD outpatient clinic, and from the NELSON study: community-based randomized lung cancer screening study, prospective cohort | • Smoking history ≥ 15 pack-years and age > 50 years (for the NELSON study) COPD (for the hospital cohort) | 527/649 (81%) - 374/495 from COPD clinic, 153/154 from NELSON study | Missing/incomplete data | Significant difference in sex, age, FEV1% predicted, BMI and follow-up time |
Cho et al. (2010), USA | 17 university-based clinics, cross-sectional | • Self-identified white subjects Physician-diagnosed COPD FEV1 ≤ 45% predicted Hyperinflation on PFT Bilateral emphysema on CT scan | 308/1220 (28%) | Missing/incomplete data | Significant difference in lung function parameters, 6MWD, PaCO2 |
DiSantostefano et al. (2013), USA, Canada 2004-2005 | Data pooled from two studies conducted across 98, and 94 research sites, respectively (setting not specified), randomized controlled trials | • ≥40 years Clinical history of COPD Pre-bronchodilator FEV1 ≤ 50% predicted, FEV1/ FVC ratio ≤ 0.7 Smoking history ≥10 pack-years Documented history of ≥1 moderate/severe COPD exacerbations in the previous year | 1543/1579 (98%) | Protocol violations | Not reported |
Garcia-Aymerich et al. (2011), Spain, Jan 2004 - March 2006 | 9 teaching hospitals, prospective cohort | • Patients hospitalized for the first time with a COPD exacerbation COPD, diagnosed 3 months after discharge, when clinically stable | 342/604 (57%) | Non-participation (213 patients refused, 23 patients discharged before the interview, 12 deaths, 14 lost to follow-up) | Significant difference in smoking status and a diagnosis of congestive heart failure |
Spinaci et al. (1985), Italy, 1979-1980 | University out-patient clinic, cross-sectional | Stable, severe COLD: FEV1 < 1.5 L and (ratio between FEV1/FVC <0.6 | 532 | Not reported | Not reported |
Vanfleteren et al. (2013), Netherlands, Nov 2007- Nov 2010 | Tertiary care referral center for pulmonary rehabilitation program, cross-sectional | • Moderate to very severe COPD (GOLD stages II–IV) 40–80 years Clinically stable | 213 | Not reported | Not reported |