Skip to main content

Advertisement

Table 2 Pharmacokinetic profile of PXS-4728A in rodents

From: Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration

  Rat Mouse
Oral dose 6 mg.kg −1 10 mg.kg −1
Bioavailability (%) 55 92
Apparent concentration at curve maximum Cmax (μg.ml−1) 0.72 1.38
Time of maximal concentration Tmax (hour) 0.83 0.25
Clearance CL (ml.kg.min−1) 45 98
Intravenous dose 3 mg.kg −1 5 mg.kg −1
Apparent concentration at curve maximum Cmax (μg.ml−1) 4.21 1.6
Time of maximal concentration Tmax (min) 0.03 0.03
Clearance CL (ml.kg.min−1) 23 80
Apparent half-life, t1/2 (h) 1.1 0.6