Skip to main content


Figure 7 | Respiratory Research

Figure 7

From: Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration

Figure 7

Inhibition of inflammation during CLP induces sepsis. Cecal ligation and puncture (CLP) was induced by ligating and perforating the cecum. Cecal contents were expressed through the perforation. The cecum was placed back into the peritoneal cavity and the peritoneal wall and skin incisions were then closed. 6 hours after surgery (A) total cells (B) and neutrophils were analysed in the peritoneal lavage. Inhibition of inflammation by VAP-1/SSAO regulation was seen in the bronchoalveolar lavage, by a decrease in (C) total cell counts, (D) neutrophils and (E) MPO. Treatment with PXS-4728A increased survival (F). N = 4-6 per group for the BALF, peritoneal lavage and MPO; N = 8/10 per group for survival; **p < 0.01, ***p < 0.001 over sham.

Back to article page