Figure 6
Expression of α-SMA mRNA in HLF following exposure to TGFβ 2, TGFβ 2 monoclonal neutralizing antibody, and PGE 2. . TGFβ2 exposure lead to a 17-fold increase in α-SMA expression (p < 0.001). This effect was decreased by nearly 50% with addition of TGFβ2 neutralizing antibody (p < 0.01). Addition of PGE2 lead to an 80% reduction in α-SMA expression compared to untreated HLF (p < 0.01).