Figure 7
IFN-γ suppresses MMP-12. To assess the effects of IFN-γ on MMP-12 production in the condition of RSV challenge, BALB/c mice were treated with IFN-γ neutralizing antibody and nude mice were treated recombinant murine IFN-γ on days 0, 1, and 3 respectively. Samples were collected on day 5. A: IFN-γ levels in BALB/c mice. B: IFN-γ levels in nude mice. C: MMP-12 levels in BALB/c mice. D: MMP-12 levels in nude mice. control: mock-infected and PBS treated mice group; RSV + anti-IFN-γ: RSV-infected and IFN-γ neutralizing antibody treated BALB/c mice group; RSV + r-IFN-γ: RSV-infected and recombinant murine IFN-γ treated nude mice group, RSV: RSV-infected and isotype control antibodies treated BALB/c mice or nude mice groups. Data are representative of two independent experiments performed on 6–10 animals per group. *, p < 0.05, **, p < 0.01, ***, p < 0.001 shown comparing the the corresponding mice groups are connected by a line.