Figure 6
TGFβR2KO mice have improved lung morphometry in hyperoxia settings. (A) Representative images of lung histology (H&E stain) of NB TGFβR2KO mice exposed to RA or 100% O2 from PN1 – PN7 with appropriate controls. Scale bar: 100 μm (B) Bar graph showing morphometric analysis of mean chord length in hyperoxia exposed PN7 TGFβR2KO mice as compared to room air controls. (C) Bar graph showing morphometric analysis of septal thickness in hyperoxia exposed PN7 TGFβR2KO mice as compared to room air controls. (D) Representative images of immunohistochemistry of myeloperoxidase (MPO) staining showing of inflammatory cells (neutrophils) in the lungs NB TGFβR2KO mice exposed to RA or 100% O2 from PN1 – PN7 with appropriate controls. Scale bar: 100 μm (E) Bar graph showing MPO levels (measured by ELISA) in hyperoxia exposed PN7 TGFβR2KO mice as compared to room air controls. N = 4 in each group; *p < 0.05, ***p < 0.001.