Figure 5
From: Inhibition of AMPK expression in skeletal muscle by systemic inflammation in COPD rats
The levels of TNF-α in both serum and muscle tissue were elevated in COPD model rats, and AICAR or resveratrol treatment decreased the COPD-based TNF-α elevation. TNF-α in serum (A; Control: n = 14, 154.70 ± 3.47; COPD/saline: n = 12, 378.09 ± 7.60; COPD/AICAR, n = 14, 248.00 ± 6.30; COPD/Resveratrol, n = 12, 255.43 ± 9.40; ***F 3, 51 = 181.12, p < 0.001 comparing to the control group; ###F 2, 37 = 87.64, p < 0.001 for COPD/AICAR group or COPD/resveratrol group compared to the COPD/saline group). TNF-α in skeletal muscle (B; Control: n = 14, 129.77 ± 3.15; COPD/saline: n = 12, 330.56 ± 6.87; COPD / AICAR, n = 14, 212.37 ± 5.49; COPD/Resveratrol, n = 12, 229.30 ± 7.64; ***F 3, 51 = 197.94, p < 0.001; ###F 2, 37 = 91.87, p < 0.001 for COPD/AICAR group or COPD/resveratrol group compared to the COPD/saline group).