Early onset persistent asthma vs. no asthma | Late onset persistent asthma vs. no asthma | Heterogeneity c | |||
---|---|---|---|---|---|
Family history of asthma | RR | RR a | RR | RR b | (Q-statistic, |
(95% CI) | (95% CI) | (95% CI) | (95% CI) | P -value) | |
Parents or siblings with asthma | 3.58 (2.37-5.41) | 4.10 (2.66-6.32) | 1.57 (0.84-2.92) | 1.44 (0.73-2.84) | 6.47, 0.01 |
Parents or siblings with allergic diseases | 2.79 (1.70-4.60) | 3.24 (1.89-5.58) | 1.43 (0.77-2.67) | 1.26 (0.67-2.38) | 4.94, 0.03 |
Maternal asthma | 3.60 (2.00-6.50) | 3.94 (2.11-7.36) | 0.92 (0.28-3.07) | 0.88 (0.28-2.81) | 4.98, 0.03 |
Maternal allergic disease | 2.89 (1.71-4.86) | 3.04 (1.72-5.35) | 1.71 (0.84-3.47) | 1.27 (0.58-2.80) | 3.07, 0.08 |
Paternal asthma | 2.70 (1.30-5.61) | 3.33 (1.57-7.06) | 2.42 (0.99-5.91) | 2.04 (0.75-5.52) | 0.60, 0.44 |
Paternal allergic disease | 1.51 (0.78-2.90) | 1.86 (0.95-3.64) | 0.63 (0.22-1.83) | 0.64 (0.22-1.80) | 2.89, 0.09 |
Both parents with asthma | 8.73 (3.80-20.04) | 9.61 (3.93-23.45) | 7.75 (2.57-23.39) | 5.46 (1.30-22.98) | 0.42, 0.51 |
Both parents with allergic disease | 3.71 (1.99-6.92) | 4.48 (2.35-8.57) | 2.58 (1.11-5.99) | 2.41 (0.98-5.94) | 1.20, 0.27 |
Siblings with asthma only | 2.96 (1.70-5.15) | 3.30 (1.84-5.92) | 0.95 (0.30-3.04) | 1.10 (0.33-3.61) | 4.44, 0.04 |
Siblings with allergic disease only | 2.08 (1.06-4.08) | 2.31 (1.11-4.78) | 1.24 (0.52-2.96) | 1.24 (0.52-2.99) | 1.13, 0.29 |
Parents with asthma only | 3.24 (1.79-5.86) | 3.89 (2.10-7.20) | 1.60 (0.70-3.62) | 1.21 (0.49-2.96) | 2.64, 0.10 |
Parents with allergic disease only | 2.43 (1.34-4.41) | 2.85 (1.51-5.39) | 1.25 (0.58-2.71) | 0.92 (0.40-2.13) | 4.41, 0.04 |
Parents and siblings with asthma | 8.19 (4.31-15.57) | 9.24 (4.68-18.22) | 3.58 (1.27-10.14) | 3.38 (1.13-10.18) | 2.31, 0.13 |
Parents and siblings with allergic disease | 4.44 (2.49-7.92) | 5.50 (2.95-10.24) | 1.96 (0.89-4.29) | 1.93 (0.87-4.30) | 3.36, 0.02 |