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Table 3 The influence of family history of asthma on persistent and transient asthma, The Espoo Cohort Study 1991–2011, Finland

From: Allergic diseases and asthma in the family predict the persistence and onset-age of asthma: a prospective cohort study

 

Persistent asthma vs. no asthma

Transient asthma vs. no asthma

Heterogeneity b

Family history of asthma

RR

RR a

RR

RR a

Q-statistic,

(95% CI)

(95% CI)

(95% CI)

(95% CI)

P -value

Parents or siblings with asthma

2.62 (1.88-3.65)

2.82 (1.99-4.00)

1.56 (0.99-2.43)

1.65 (1.03-2.65)

3.20, 0.07

Parents or siblings with allergic diseases

2.11 (1.45-3.09)

2.20 (1.48-3.28)

0.98 (0.65-1.49)

1.02 (0.66-1.58)

6.50, 0.01

Maternal asthma

2.42 (1.47-3.98)

2.50 (1.50-4.15)

1.64 (0.89-3.04)

1.57 (0.79-3.11)

1.35, 0.25

Maternal allergic disease

2.31 (1.54-3.46)

2.17 (1.40-3.37)

1.44 (0.88-2.38)

1.48 (0.87-2.52)

1.18, 0.77

Paternal asthma

2.47 (1.43-4.28)

2.70 (1.52-4.80)

0.97 (0.39-2.40)

1.10 (0.44-2.73)

0.85, 0.35

Paternal allergic disease

1.13 (0.66-1.94)

1.29 (0.75-2.22)

1.07 (0.61-1.91)

1.20 (0.67-2.15)

0.03, 0.86

Both parents with asthma

6.92 (3.76-12.71)

6.70 (3.34-13.45)

2.64 (0.71-9.86)

2.94 (0.80-10.87)

4.24, 0.04

Both parents with allergic disease

3.05 (1.88-4.95)

3.32 (2.01-5.47)

1.07 (0.46-2.45)

0.97 (0.39-2.40)

5.41, 0.02

Siblings with asthma only

2.11 (1.31-3.40)

2.33 (1.42-3.84)

1.62 (0.85-3.09)

1.79 (0.93-3.45)

7.36, 0.01

Siblings with allergic disease only

1.67 (0.99-2.80)

1.75 (1.02-3.01)

0.57 (0.26-1.27)

0.63 (0.28-1.41)

4.27, 0.04

Parents with asthma only

2.41 (1.52-3.84)

2.50 (1.54-4.06)

1.55 (0.88-2.73)

1.56 (0.85-2.87)

4.29, 0.04

Parents with allergic disease only

1.84 (1.16-2.92)

1.82 (1.12-2.97)

1.19 (0.74-1.91)

1.23 (0.75-2.03)

1.20, 0.27

Parents and siblings with asthma

5.52 (3.31-9.20)

5.97 (3.48-10.22)

1.39 (0.45-4.32)

1.64 (0.52-5.14)

17.40, 0.00

Parents and siblings with allergic disease

3.13 (2.00-4.90)

3.48 (2.18-5.56)

1.01 (0.55-1.84)

1.02 (0.54-1.92)

9.40, 0.00

  1. 19 People excluded from the analyses due to follow-up period of less than 5 years (n = 8) or asthma relapse (n = 11).
  2. aAdjusted for sex, age, family socioeconomic status at baseline, maternal smoking in pregnancy, SHS at the age of 0–3, mold exposure at the age of 0–3, and duration of breast-feeding.
  3. bHeterogeneity calculated between the adjusted risk ratios of persistent and transient asthma.