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Table 3 The influence of family history of asthma on persistent and transient asthma, The Espoo Cohort Study 1991–2011, Finland

From: Allergic diseases and asthma in the family predict the persistence and onset-age of asthma: a prospective cohort study

  Persistent asthma vs. no asthma Transient asthma vs. no asthma Heterogeneity b
Family history of asthma RR RR a RR RR a Q-statistic,
(95% CI) (95% CI) (95% CI) (95% CI) P -value
Parents or siblings with asthma 2.62 (1.88-3.65) 2.82 (1.99-4.00) 1.56 (0.99-2.43) 1.65 (1.03-2.65) 3.20, 0.07
Parents or siblings with allergic diseases 2.11 (1.45-3.09) 2.20 (1.48-3.28) 0.98 (0.65-1.49) 1.02 (0.66-1.58) 6.50, 0.01
Maternal asthma 2.42 (1.47-3.98) 2.50 (1.50-4.15) 1.64 (0.89-3.04) 1.57 (0.79-3.11) 1.35, 0.25
Maternal allergic disease 2.31 (1.54-3.46) 2.17 (1.40-3.37) 1.44 (0.88-2.38) 1.48 (0.87-2.52) 1.18, 0.77
Paternal asthma 2.47 (1.43-4.28) 2.70 (1.52-4.80) 0.97 (0.39-2.40) 1.10 (0.44-2.73) 0.85, 0.35
Paternal allergic disease 1.13 (0.66-1.94) 1.29 (0.75-2.22) 1.07 (0.61-1.91) 1.20 (0.67-2.15) 0.03, 0.86
Both parents with asthma 6.92 (3.76-12.71) 6.70 (3.34-13.45) 2.64 (0.71-9.86) 2.94 (0.80-10.87) 4.24, 0.04
Both parents with allergic disease 3.05 (1.88-4.95) 3.32 (2.01-5.47) 1.07 (0.46-2.45) 0.97 (0.39-2.40) 5.41, 0.02
Siblings with asthma only 2.11 (1.31-3.40) 2.33 (1.42-3.84) 1.62 (0.85-3.09) 1.79 (0.93-3.45) 7.36, 0.01
Siblings with allergic disease only 1.67 (0.99-2.80) 1.75 (1.02-3.01) 0.57 (0.26-1.27) 0.63 (0.28-1.41) 4.27, 0.04
Parents with asthma only 2.41 (1.52-3.84) 2.50 (1.54-4.06) 1.55 (0.88-2.73) 1.56 (0.85-2.87) 4.29, 0.04
Parents with allergic disease only 1.84 (1.16-2.92) 1.82 (1.12-2.97) 1.19 (0.74-1.91) 1.23 (0.75-2.03) 1.20, 0.27
Parents and siblings with asthma 5.52 (3.31-9.20) 5.97 (3.48-10.22) 1.39 (0.45-4.32) 1.64 (0.52-5.14) 17.40, 0.00
Parents and siblings with allergic disease 3.13 (2.00-4.90) 3.48 (2.18-5.56) 1.01 (0.55-1.84) 1.02 (0.54-1.92) 9.40, 0.00
  1. 19 People excluded from the analyses due to follow-up period of less than 5 years (n = 8) or asthma relapse (n = 11).
  2. aAdjusted for sex, age, family socioeconomic status at baseline, maternal smoking in pregnancy, SHS at the age of 0–3, mold exposure at the age of 0–3, and duration of breast-feeding.
  3. bHeterogeneity calculated between the adjusted risk ratios of persistent and transient asthma.
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