Table 1 Characteristics of patients
From: Delay of airway epithelial wound repair in COPD is associated with airflow obstruction severity
Non COPD | COPD | p | |
|---|---|---|---|
n | 7 | 13 | |
Male gender | 71% | 85% | ns |
Age, years | 69 ± 10 [58–87] | 66 ± 10 [52–84] | ns |
BMI, kg/m2 | 33 ± 9 [26–43] | 25 ± 4 [19–35] | 0.04 |
Smoking history | |||
Never smokers | 29% | 0% | ns |
Ex smokers | 43% | 54% | ns |
Pack-years | 29 ± 25 [0–60] | 54 ± 22 [25–100] | ns |
Symptoms | |||
Dyspnea ≥2 mMRC | 0% | 31% | ns |
Chronic bronchitis | 14% | 31% | ns |
At least one exacerbation in the last year | na | 31% | |
Spirometry | |||
FEV1,% of predicted value | 94 ± 15 [72–113] | 68 ± 29 [17–109] | 0.04 |
FVC,% of predicted value | 90 ± 13 [77–114] | 89 ± 23 [54–117] | ns |
FEV1/FVC,% | 77 ± 5 [73–87] | 59 ± 17 [27–69] | 0.01 |
Spirometric GOLD 1/2/3-4 | na | 5/5/3 | |
GOLD A/B/C/D | na | 5/5/0/3 | |
CT emphysema score for the resected lobe | 0.4 + 0.8 [0–2] | 1.3 + 1.7 [0–4] | ns |
Histological analyses,% of epithelial surface, n = 17 | |||
Denuded basement membrane | 3.8 ± 5.0 [0–13] | 5.4 ± 4.0 [0–14] | ns |
Goblet cell hyperplasia | 51.7 ± 23.4 [7–80] | 48.6 ± 24.4 [16–82] | ns |
Basal cell hyperplasia | 4.2 ± 4.6 [0–14] | 12.6 ± 22.2 [0–70] | ns |
Squamous metaplasia | 2.2 ± 1.8 [0–5] | 2.1 ± 3.2 [0–9] | ns |
Normal | 38.0 ± 22.2 [10–87] | 32.7 ± 23.0 [3–66] | ns |