Table 2 GWAS findings for FEV 1 in the LLFS (p <1E-07) and replication in the CHARGE/SpiroMeta consortia
From: Genetic variants associated with lung function: the long life family study
LLFS | CHARGE/SPIROMETA CONSORTIA | META ANALYSIS | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SNP | Chromosomal position | Gene | Coded/non-coded allele | Coded allele frequency | β (SE) | P_value | Coded allele frequency | β (SE) | P_value | Coded allele frequency | β (SE) | P_value | HetPVal | N |
rs9390140 | Chr 6: 144127026 | PHACTR2 | C/G | 0.33 | −0.121(0.025) | 8.83E-07 | 0.33 | 0.002(0.008) | 0.78 | 0.33 | −0.008(0.007) | 0.25 | 1.80E-06 | 51073 |
rs1493126 | Chr 4:108855828 | CYP2U1 | C/G | 0.23 | 0.139(0.028) | 8.24E-07 | 0.22 | −0.005(0.009) | 0.53 | 0.22 | 0.007(0.008) | 0.42 | 9.48E-07 | 51687 |
rs4956031* | Chr4: 108857140 | CYP2U1 | T/C | 0.23 | 0.138(0.028) | 9.17E-07 | 0.22 | −0.005(0.009) | 0.52 | 0.22 | 0.007(0.008) | 0.43 | 1.04E-06 | 51715 |
rs998405 | Chr4: 108862837 | CYP2U1 | C/G | 0.23 | 0.139(0.028) | 7.93E-07 | 0.22 | −0.006(0.009) | 0.50 | 0.22 | 0.006(0.008) | 0.43 | 8.18E-07 | 51501 |
rs17564501 | Chr4: 108863209 | CYP2U1 | A/C | 0.77 | −0.139(0.028) | 7.93E-07 | 0.78 | 0.006(0.009) | 0.50 | 0.78 | −0.006(0.008) | 0.44 | 8.15E-07 | 51456 |
rs1493122 | Chr4: 108864651 | CYP2U1 | T/C | 0.77 | −0.139(0.028) | 7.59E-07 | 0.79 | 0.006(0.009) | 0.47 | 0.78 | −0.006(0.008) | 0.46 | 7.40E-07 | 51105 |
rs1493131* | Chr4: 108860906 | CYP2U1 | A/G | 0.23 | 0.139(0.028) | 7.37E-07 | 0.22 | −0.006(0.009) | 0.47 | 0.22 | 0.006(0.008) | 0.46 | 7.23E-07 | 51877 |
rs11724895 | Chr4: 108865791 | CYP2U1 | C/G | 0.77 | −0.139(0.028) | 7.72E-07 | 0.79 | 0.006(0.009) | 0.46 | 0.78 | −0.006(0.008) | 0.47 | 8.06E-07 | 51068 |
rs17564543 | Chr4: 108863481 | CYP2U1 | T/C | 0.77 | −0.138(0.028) | 9.07E-07 | 0.78 | 0.007(0.009) | 0.40 | 0.78 | −0.005(0.008) | 0.53 | 7.47E-07 | 50935 |