Figure 5
From: Small interfering RNA against CD86 during allergen challenge blocks experimental allergic asthma
Effect of treatment with CD86 siRNA on allergic asthmatic response. (A) CD86 siRNA or control siRNA was administrated intratracheally 1 hour before each OVA challenge. (B) Airway hyperresponsiveness to inhaled acetylcholine (ACh) was measured 36 hours after the last OVA challenge. (C) Cell counts in BAL fluids were performed. Mo = macrophage; Neut = neutrophil; Ly = lymphocyte; Eo = eosinophil. (D) Serum OVA-IgE levels were analyzed. (E) Cytokine levels and TARC levels in BAL fluids were analyzed. All data mean ± SEM of 8–12 mice per group. * and † indicate statistically significant (P <0.05) difference between the indicated two groups.