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Table 5 E-RS Responder estimates using distribution-based methods by trial: ½ SD and SEM *

From: Measuring respiratory symptoms of COPD: performance of the EXACT- Respiratory Symptoms Tool (E-RS) in three clinical trials

Scale Method Mpex AZ 1 AZ 2
(N = 235) (N = 749) (N = 597)
RS-Total    
½ SD 2.97 3.00 2.995
 SEM 1.88 1.47 1.34
RS-Breathlessness    
½ SD 2.97 1.59 1.56
 SEM 1.57 0.78 0.76
RS-Cough and Sputum    
½ SD 1.04 0.78 0.80
 SEM 1.44 0.81 0.75
RS-Chest Symptoms    
½ SD 1.04 0.97 0.96
 SEM 0.42 0.47 0.51
  1. *SEM=SD 1 - α .
  2. Weekly scores at baseline, Day -7 to Day 1; Ranges: RS-Total: 0 to 40; RS-Breathlessness: 0 to 17; RS-Cough and Sputum: 0 to 11; RS-Chest Symptoms: 0 to 12; higher scores = more severe symptoms.
  3. Abbreviations: AZ AstraZeneca, E-RS Exacerbations of Chronic Pulmonary Disease Tool – Respiratory Symptoms, SD standard deviation, SEM standard error of measurement.