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Table 3 Correlations between E-RS scores and airway obstruction, respiratory symptom severity, and rescue medication use

From: Measuring respiratory symptoms of COPD: performance of the EXACT- Respiratory Symptoms Tool (E-RS) in three clinical trials

  Mpex AZ 1 AZ 2
FEV1% predicted(N = 234) mMRC(N = 235) FEV1% predicted(N = 746) BCSS total score§(N = 735) Rescue medication use§(N = 735) FEV1% predicted(N = 596) BCSS total score§(N = 586) Rescue medication use§(N = 597)
E-RS Scores         
 RS-Total Score -0.19** 0.40*** -0.14*** 0.89*** 0.43*** -0.15*** 0.89*** 0.42***
 RS-Breathlessness -0.32*** 0.46*** -0.17*** 0.80*** 0.42*** -0.21*** 0.77*** 0.43***
 RS-Cough and Sputum -0.05 0.16* -0.12*** 0.89*** 0.38*** -0.06 0.92*** 0.33***
 RS-Chest Symptoms 0.03 0.27*** -0.07* 0.75*** 0.33*** -0.09* 0.79*** 0.36***
  1. Spearman's rank-order correlation; E-RS mean weekly scores at baseline (Day -7 to Day -1).
  2. Clinic visit, Day 1, prior to treatment.
  3. §Diary: BCSS scores at baseline (Day -7 to Day -1); rescue medication (baseline, Day -1).
  4. Bold coefficients identify constructs with strongest expected relationship.
  5. *p < 0.05; **p < 0.01; ***p < 0.001.
  6. Abbreviations: AZ AstraZeneca, BCSS Breathlessness, Cough and Sputum Scale, E-RS Exacerbations of Chronic Pulmonary Disease Tool – Respiratory Symptoms, FEV 1 forced expiratory volume in 1 second, mMRC modified Medical Research Council dyspnoea scale.