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Table 3 Correlations † between E-RS scores and airway obstruction, respiratory symptom severity, and rescue medication use

From: Measuring respiratory symptoms of COPD: performance of the EXACT- Respiratory Symptoms Tool (E-RS) in three clinical trials

 

Mpex

AZ 1

AZ 2

FEV1% predicted‡(N = 234)

mMRC‡(N = 235)

FEV1% predicted‡(N = 746)

BCSS total score§(N = 735)

Rescue medication use§(N = 735)

FEV1% predicted‡(N = 596)

BCSS total score§(N = 586)

Rescue medication use§(N = 597)

E-RS Scores

        

 RS-Total Score

-0.19**

0.40***

-0.14***

0.89***

0.43***

-0.15***

0.89***

0.42***

 RS-Breathlessness

-0.32***

0.46***

-0.17***

0.80***

0.42***

-0.21***

0.77***

0.43***

 RS-Cough and Sputum

-0.05

0.16*

-0.12***

0.89***

0.38***

-0.06

0.92***

0.33***

 RS-Chest Symptoms

0.03

0.27***

-0.07*

0.75***

0.33***

-0.09*

0.79***

0.36***

  1. †Spearman's rank-order correlation; E-RS mean weekly scores at baseline (Day -7 to Day -1).
  2. ‡Clinic visit, Day 1, prior to treatment.
  3. §Diary: BCSS scores at baseline (Day -7 to Day -1); rescue medication (baseline, Day -1).
  4. Bold coefficients identify constructs with strongest expected relationship.
  5. *p < 0.05; **p < 0.01; ***p < 0.001.
  6. Abbreviations: AZ AstraZeneca, BCSS Breathlessness, Cough and Sputum Scale, E-RS Exacerbations of Chronic Pulmonary Disease Tool – Respiratory Symptoms, FEV 1 forced expiratory volume in 1 second, mMRC modified Medical Research Council dyspnoea scale.
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Respiratory Research

ISSN: 1465-993X

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