Table 4 Patient-reported outcomes in patients with/without COPD symptoms during each part of the 24-hour day

mMRC grade,

1.6

1.9

<0.001

1.4

1.9

<0.001

1.4

1.9

<0.001

mean (95% CI)

(1.5, 1.7)

(1.8, 2.0)

(1.2, 1.5)

(1.8, 2.0)

(1.2, 1.6)

(1.8, 2.0)

(n = 265)

(n = 457)

(n = 134)

(n = 591)

(n = 124)

(n = 600)

CAT score,

11.6

19.3

<0.001

9.8

18.1

<0.001

10.0

17.9

<0.001

mean (95% CI)

(10.8, 12.4)

(18.6, 20.0)

(8.8, 10.9)

(17.4, 18.7)

(8.9, 11.1)

(17.3, 18.5)

(n = 263)

(n = 455)

(n = 133)

(n = 588)

(n = 124)

(n = 596)

HADS anxiety score,

4.6

6.9

<0.001

4.1

6.5

<0.001

4.2

6.5

<0.001

mean (95% CI)

(4.1, 5.1)

(6.5, 7.3)

(3.4, 4.7)

(6.2, 6.9)

(3.5, 4.8)

(6.1, 6.8)

(n = 262)

(n = 445)

(n = 133)

(n = 577)

(n = 123)

(n = 586)

HADS depression score,

4.2

6.2

<0.001

3.4

6.0

<0.001

3.7

5.9

<0.001

mean (95% CI)

(3.8, 4.6)

(5.8, 6.6)

(2.9, 4.0)

(5.6, 6.3)

(3.1, 4.4)

(5.5, 6.2)

(n = 263)

(n = 448)

(n = 132)

(n = 582)

(n = 123)

(n = 590)

CASIS score,

33.6

50.2

<0.001

34.4

46.3

<0.001

34.2

46.2

<0.001

mean (95% CI)

(31.9, 35.2)

(48.4, 52.0)

(31.7, 37.1)

(44.8, 47.9)

(31.4, 37.0)

(44.7, 47.8)

(n = 260)

(n = 449)

(n = 131)

(n = 581)

(n = 122)

(n = 589)