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Table 2 Morphometric analysis of lungs from CSF-1-treated mice after 7 days of neonatal hyperoxia exposure

From: The effect of CSF-1 administration on lung maturation in a mouse model of neonatal hyperoxia exposure

   Normoxia Hyp + PBS Hyp + CSF-1
P11 % Tissue 50.66 ± 1.61 53.62 ± 2.99 52.98 ± 1.90
  % Airspace 49.34 ± 1.61 46.38 ± 2.99 47.02 ± 1.90
  MLI 88.59 ± 2.42 94.33 ± 2.37 87.42 ± 0.99
P35 % Tissue 36.97 ± 1.29 39.15 ± 2.01 35.92 ± 0.87
  % Airspace 63.03 ± 1.29 60.85 ± 2.01 64.08 ± 0.87
  MLI 64.99 ± 1.78 68.67 ± 1.64 67.34 ± 1.63
  1. Morphometric estimation of percentage tissue, percentage airspace and mean linear intercept (MLI) at P11 (n = 4 lungs/treatment) and P35 (n = 6-7 lungs/treatment) in newborn mice exposed to normoxia or hyperoxia for 7 days followed by either CSF-1 or PBS treatment for 5 consecutive days. No significant changes were observed in the morphometric parameters examined amongst the three treatment groups. Data were analysed using one-way ANOVAs and Tukey’s post-hoc tests.