NE increases expression of PlGF and activation of JNK and PKCδ signaling. (A and B) Paraffin-embedded lung tissue sections were used for immuno-histochemistry (IHC) analysis and incubated with antibodies of PlGF, p-JNK and p-PKCδ. Arrow heads indicated positive stain of PlGF, p-JNK and p-PKCδ in LE cells. (C) Mice broncho-alveolar lavage fluid was analyzed for the PlGF level by ELISA. Scale bar = 200 μm. Data are presented as mean ± SEM. *p < 0.05 vs. vehicle-treated group; #p < 0.05 vs. corresponding WT group.