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Table 1 Demographic details of study participants

From: Increased levels of soluble interleukin-6 receptor and CCL3 in COPD sputum

 

COPD (n = 59)

S (n = 15)

HNS (n = 15)

p-value

Sex (F:M)

23:36

8:7

4:11

-

Age*

67 (45–75)

52 (38–62)

32 (19–75)

p < 0.0001

Pack years smoked*§

34.9 (12.5-122.2)

29 (15–67)

0

ns

Current smokers (%)

41

100

0

-

ICS users (%)

67.8

-

-

-

Chronic Bronchitis (n) (%)

35 (59%)

-

-

-

FEV1% predicted1a

61.6 (18.1)

95.7 (13.0)

116.7 (13.8)

p < 0.0001

FEV1/FVC %1*

51.0 (28.9-67.0)

74.8 (70.5-80.8)

85.7 (72.6-101.6)

p < 0.0001

FEV1 % predicted2a

64.5 (17.2)

98.64 (12.1)

117.9 (14.3)

p < 0.0001

FEV1/FVC %2*

57.1 (25.8-69.6)

73.0 (70.2-82.5)

86.1 (80.7-93.7)

p < 0.0001

IC (L)1a

2.2 (0.7)

-

-

-

TLC% predicted1*

102.3 (8.4-164.7)

-

-

-

KCO% predicted1a

88.1 (25)

-

-

-

6MWT distance (m)*

387 (28–540)

-

-

-

SGRQ (total)a

37 (19.8)

-

-

-

mMRCa

1.2 (1)

-

-

-

CATa

17.5 (7.9)

-

-

-

  1. *Data presented as median (range). aData presented as mean (SD). 1Pre-bronchodilator. 2Post-bronchodilator. Explanation of abbreviations: IC = Inspiratory capacity, TLC = total lung capacity, KCO = transfer coefficient, 6MWT = 6 minute walk test, SGRQ = St George’s respiratory questionnaire, mMRC = modified Medical Research Council Dyspnoea score, CAT = COPD assessment tool, ns = not significant. The statistical significance of differences between groups was determined using either ANOVA + Tukey’s multiple comparison test or Kruskal-Wallis + Dunn’s post-test (for analysis of parametric and non-parametric data respectively). §Mann–Whitney U test was performed to assess the statistical significance of differences in pack-year smoking history between COPD & S.