Skip to main content

Table 1 Demographic details of study participants

From: Increased levels of soluble interleukin-6 receptor and CCL3 in COPD sputum

  COPD (n = 59) S (n = 15) HNS (n = 15) p-value
Sex (F:M) 23:36 8:7 4:11 -
Age* 67 (45–75) 52 (38–62) 32 (19–75) p < 0.0001
Pack years smoked*§ 34.9 (12.5-122.2) 29 (15–67) 0 ns
Current smokers (%) 41 100 0 -
ICS users (%) 67.8 - - -
Chronic Bronchitis (n) (%) 35 (59%) - - -
FEV1% predicted1a 61.6 (18.1) 95.7 (13.0) 116.7 (13.8) p < 0.0001
FEV1/FVC %1* 51.0 (28.9-67.0) 74.8 (70.5-80.8) 85.7 (72.6-101.6) p < 0.0001
FEV1 % predicted2a 64.5 (17.2) 98.64 (12.1) 117.9 (14.3) p < 0.0001
FEV1/FVC %2* 57.1 (25.8-69.6) 73.0 (70.2-82.5) 86.1 (80.7-93.7) p < 0.0001
IC (L)1a 2.2 (0.7) - - -
TLC% predicted1* 102.3 (8.4-164.7) - - -
KCO% predicted1a 88.1 (25) - - -
6MWT distance (m)* 387 (28–540) - - -
SGRQ (total)a 37 (19.8) - - -
mMRCa 1.2 (1) - - -
CATa 17.5 (7.9) - - -
  1. *Data presented as median (range). aData presented as mean (SD). 1Pre-bronchodilator. 2Post-bronchodilator. Explanation of abbreviations: IC = Inspiratory capacity, TLC = total lung capacity, KCO = transfer coefficient, 6MWT = 6 minute walk test, SGRQ = St George’s respiratory questionnaire, mMRC = modified Medical Research Council Dyspnoea score, CAT = COPD assessment tool, ns = not significant. The statistical significance of differences between groups was determined using either ANOVA + Tukey’s multiple comparison test or Kruskal-Wallis + Dunn’s post-test (for analysis of parametric and non-parametric data respectively). §Mann–Whitney U test was performed to assess the statistical significance of differences in pack-year smoking history between COPD & S.