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Table 2 Meta-analysis results of three genome-wide association studies for total lung capacity measured by CT in COPD subjects *

From: DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease

Locus SNP Nearest Gene Distance (kb) Risk/Non-risk Allele FRQ COPDGene NHW ECLIPSE GenKOLS Overall I 2 Q
       β P β P β P β P   
5p15.2 rs114929486 DNAH5 0 A/G 0.04 0.37 2.94 × 10-4 0.60 7.18 × 10-6 0.13 5.47 × 10-1 0.42 4.66 × 10-8 49 0.14
8q24.12 rs10955930 ENPP2 30 T/A 0.49 0.11 5.55 × 10-4 0.15 1.19 × 10-3 0.22 7.45 × 10-3 0.13 1.38 × 10-7 0 0.37
19p13.12 rs590950 CYP4F8 26 T/C 0.49 0.13 3.36 × 10-6 0.09 3.79 × 10-2 0.13 1.25 × 10-1 0.12 1.39 × 10-7 0 0.72
6q13 rs72920744 B3GAT2 6 G/A 0.99 0.40 8.05 × 10-3 0.83 6.32 × 10-6 0.61 1.11 × 10-1 0.58 2.18 × 10-7 39 0.19
8q24.3 rs57629580 LY6H 35 C/A 0.91 0.30 1.47 × 10-5 0.27 4.02 × 10-3 0.10 6.05 × 10-1 0.28 2.56 × 10-7 0 0.66
  1. Definition of abbreviations: FRQ = risk allele frequency; NHW = non-Hispanic white; SNP = single nucleotide polymorphism.
  2. *Adjusted for age, sex, height, pack-years of cigarette smoking and genetic ancestry as summarized in the principal components.
  3. Imputed genotypes.