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Table 2 Meta-analysis results of three genome-wide association studies for total lung capacity measured by CT in COPD subjects *

From: DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease

Locus

SNP

Nearest Gene

Distance (kb)

Risk/Non-risk Allele

FRQ

COPDGene NHW

ECLIPSE

GenKOLS

Overall

I 2

Q

      

β

P

β

P

β

P

β

P

  

5p15.2

rs114929486

DNAH5

0

A/G

0.04

0.37†

2.94 × 10-4

0.60†

7.18 × 10-6

0.13†

5.47 × 10-1

0.42

4.66 × 10-8

49

0.14

8q24.12

rs10955930

ENPP2

30

T/A

0.49

0.11†

5.55 × 10-4

0.15†

1.19 × 10-3

0.22†

7.45 × 10-3

0.13

1.38 × 10-7

0

0.37

19p13.12

rs590950

CYP4F8

26

T/C

0.49

0.13†

3.36 × 10-6

0.09†

3.79 × 10-2

0.13†

1.25 × 10-1

0.12

1.39 × 10-7

0

0.72

6q13

rs72920744

B3GAT2

6

G/A

0.99

0.40†

8.05 × 10-3

0.83†

6.32 × 10-6

0.61†

1.11 × 10-1

0.58

2.18 × 10-7

39

0.19

8q24.3

rs57629580

LY6H

35

C/A

0.91

0.30†

1.47 × 10-5

0.27†

4.02 × 10-3

0.10†

6.05 × 10-1

0.28

2.56 × 10-7

0

0.66

  1. Definition of abbreviations: FRQ = risk allele frequency; NHW = non-Hispanic white; SNP = single nucleotide polymorphism.
  2. *Adjusted for age, sex, height, pack-years of cigarette smoking and genetic ancestry as summarized in the principal components.
  3. †Imputed genotypes.