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Table 1 Demographics of the study population and biologic samples for analysis of aging signature gene expression in the small airway epithelium 1

From: Smoking accelerates aging of the small airway epithelium

Parameter Healthy nonsmokers Healthy smokers p value6
n 29 29  
Gender (M/F) 16/13 22/7  
Age (yr) 38.0 ± 12.4 38.8 ± 10.1 >0.8
Race (B/W/O)2 10/8/11 13/8/8  
Smoking history (pack-yr) 0 17.8 ± 8.4  
Urine nicotine (ng/ml) negative 1657 ± 1527  
Urine cotinine (ng/ml) negative 1929 ± 1060  
Pulmonary function parameters3    
FVC 106.9 ± 12.1 111.1 ± 11.6 >0.17
FEV1 106.3 ± 12.2 109.4 ± 13.1 >0.35
FEV1/FVC 82.8 ± 4.9 81.0 ± 4.3 >0.13
TLC 99.7 ± 17.3 97.6 ± 14.1 >0.6
DLCO 90.4 ± 9.6 86.0 ± 5.4 <0.04
Body mass index (BMI) 26.4 ± 5.3 27.8 ± 4.8 >0.3
Epithelial cells4    
% epithelial cells 98.9 ± 0.9 99.2 ± 0.8 >0.2
% inflammatory cells 1.0 ± 0.8 0.8 ± 0.8 >0.2
Differential cell count5    
Ciliated (%) 71.3 ± 5.3 62.9 ± 6.9 <0.00001
Secretory (%) 10.0 ± 4.5 12.3 ± 6.4 >0.12
Basal (%) 9.5 ± 6.6 9.6 ± 6.6 >0.96
Undifferentiated columnar (%) 8.2 ± 4.9 14.5 ± 8.2 <0.001
  1. 1Data is presented as mean ± standard deviation.
  2. 2B = Black, W = White, O = Other.
  3. 3Pulmonary function testing parameters are given as % predicted value with the exception of FEV1/FVC, which is reported as % observed; FVC - forced vital capacity, FEV1 - forced expiratory volume in 1 sec. FVC, FEV1 and FEV1/FVC are post-bronchodilator values. TLC - total lung capacity, DLCO - diffusing capacity of the lung for carbon monoxide.
  4. 4Small airway epithelium.
  5. 5As % of small airway epithelium recovered.
  6. 6Smoker vs Nonsmoker comparison by student’s t-test with p < 0.05 being significant.