The heterotopic tracheal allograft as an animal model of obliterative bronchiolitis

Respiratory Research

Table 5 The effect of non-immunosuppressive interventions in the tracheal allograft model

		Dose	Treatment time	Harvest	Luminal	Epithelial
Animal	Compound	(mg/kg per day)	(days)	time (days)	occlusion (%)	loss (%)	n	Reference
Rat	Control	-	0–3	3	3	90	12	[27]
			0–10	10	10	98	10
			0–30	30	79	100	14
	Aminoguanidine	400 i.p.	0–3	3	10	76	12
			0–10	10	21	96	15
			0–30	30	92	100	14
	L-Arginine	2.25% in drinking water	0–3	3	1	53	12
			0–10	10	10	60	15
			0–30	30	53	93	12
Rat	Control	-	–1–10	10	17	80	10	[28]
			–1–30	30	85	100	10
	CGP 53716	50 i.p.	–1–10	10	6	67	10
			–1–30	30	44	100	10
Rat	Control	-	1–21	21	83		n.r.	[73]
	Losartan	80 in drinking water	1–21	21	83
			5–21	21	30
Rat	Control	-	–5–21	21	83	100	5	[48]
	Captopril	100 in drinking water	–5–21	21	45	100	5
			1–21	21	26	100	5
			5–21	21	83	100	5

ISSN: 1465-993X